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KMID : 1134820160450020181
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 2 p.181 ~ p.187
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Anti-Inflammatory Effect of Grateloupia imbricata Holmes Ethanol Extract on LPS-Induced RAW 264.7 Cells
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Kim Min-Ji
Bae Nan-Young
Kim Koth-Bong-Woo-Ri
Park Ji-Hye
Park Sun-Hee
Choi Jung-Soo
Ahn Dong-Hyun
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Abstract
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Algae is a potential resource with various biological activities. In this study, the anti-inflammatory effect of Grateloupia imbricata Holmes ethanol extract (GIHEE) from red algae was investigated in LPS-induced RAW 264.7 cells. As a result, reduced secretion of pro-inflammatory cytokines [tumor necrosis factors-α, interleukin (IL)-1β, and IL-6] and nitric oxide (NO) was observed in a dose-dependent manner. Expression of nuclear factor-kappaB (NF-κB) as well as inducible NO synthase and cyclooxygenase-2 proteins was reduced by GIHEE, suggesting that the anti-inflammatory activity of GIHEE is related to suppression of NF-κB signaling pathways. In addition, GIHEE reduced phosphorylation of mitogen-activated protein kinases. These results suggest that GIHEE can be used as a potential anti-inflammatory therapeutic.
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KEYWORD
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Grateloupia imbricata Holmes, anti-inflammation, NF-kappaB, MAPKs
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